If cancer is detected and diagnosed before symptoms appear, it can be treated more effectively and may improve efficacy. To this end, IBM scientists have invented a new chip technology that enables the separation of biological particles on a much smaller metric than previous technologies.
The study, published in Nature Nanotechnology, says the technology is capable of separating biological particles at the nanoscale, a measure that is likely to be 50 times smaller than the particle size previously detected by previous technologies. In this way, the doctor can analyze particles such as DNA, viruses, and foreign bodies, and can find the signs of the disease before showing physical symptoms.
According to IBM, the device uses nanometer-scale deterministic lateral displacement (also known as nano-DLD) to allow liquid samples to flow through a silicon chip. The chip has an asymmetric columnar array that separates the swarmed nanoparticles according to the size of the particles. The chip is 2 cm long and wide.
Exosomes are often concealed in body fluids that are easily collected, such as saliva and urine, and the biomarkers contained therein are increasingly prominent in the detection of malignant tumors. IBM technology invented the chip in the face of the challenges of current technology in the application of minimally invasive liquid biopsy. According to IBM, the lab can separate particles as small as 20 nanometers and distinguish small foreign bodies from large foreign bodies. By analyzing the size of the foreign body and the surface protein, the doctor can know the state of the cancer and discover other possible diseases.
IBM is currently working with Mount Mohan Icahn School of Medicine to focus on the development of prostate cancer cell detection technology. The device is capable of detecting foreign bodies with specific biomarkers of prostate cancer cells by liquid biopsy, and the team will test the device's detection capabilities.
In addition to early detection of cancer cells and other diseases such as flu and Zika virus, the Monet Hill team hopes that this technology will further understand disease biology because they believe that this technology can "eave" the intercellular cells carried by foreign bodies. The message of communication", thereby increasing the understanding of the disease.
Carlos Cordon-Cardo, professor and chair of the Sinai Mountain Pathology and Health Systems Department, said, "We hope to combine the expertise of the Monet Hill team in cancer and pathology with IBM's Systematic biology experience and its latest nanoscale separation technology find specific, easily detectable biomarkers from exosomes to create a new cutting-edge technology to further determine whether an individual has cancer and how to better treat it. â€
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